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Semaglutide and Tirzepatide are advanced peptides that mimic gut hormones to reduce appetite and reset body weight

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Common side effects, such as nausea, vomiting, and gastrointestinal disturbances, can lead to patient non-compliance or early discontinuation of therapy

The outcomes discussed or implied in this article may not be typical and should not be considered guarantees of similar results

That is, investigations are warranted to better understand the potential benefit of combined use of GLP-1 RAs and SGLT2 inhibitors in HF with specific focus on the sequence of treatment initiation and the suitable population, including by HF phenotype and presence of diabetes