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doi: 10.1016/J.NEUROPHARM.2018.11.002

Preclinical Models and Behavioral Paradigms Preclinical studies used validated behavioral paradigms to evaluate substance-seeking behavior, including oral self-administration, intravenous administration, drug- and cue-induced reinstatement, conditioned place preference, and operant conditioning

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The GCGR activation stimulates glucagon secretion, which elevates blood glucose

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