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A 2022 systematic review and meta-analysis published in JAMA Internal Medicine found that GLP-1 receptor agonists were associated with increased risks of biliary disease compared to other diabetes medications, with higher risk observed at weight-loss doses and with longer duration of treatment

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The PlexusDx Precision Peptide Genetic Test ($99 add-on after your first month of treatment) maps 14 metabolic pathways and identifies variants like GLP1R rs6923761 and GIPR rs1800437 that predict your sensitivity to GLP-1 therapy

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