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This recent work emphasises that microbiome changes in type 2 diabetes are predominantly associated with metformin, rather than type 2 diabetes itself, although their role as cause or consequence of therapeutic benefit requires further investigation

and Holst J
Rybelsus vs Trulicity: Which has better A1C reduction
exendin-4, in keeping with their acute trafficking differences
July 25, 2025

( 10.2337/db18-1149) [DOI] [PubMed] [Google Scholar] Smith C Patterson-Cross R Woodward O Lewis J Chiarugi D Merkle F Gribble F Reimann F & Adriaenssens A
