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2022 JAMA Internal Medicine meta-analysis: pooling 76 randomised controlled trials, GLP-1 receptor agonist use was associated with a relative risk of 1.37 for biliary disease compared with placebo or other treatments

Lilly has not yet filed for Food and Drug Administration approval but could do so this year

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For example, ICD diagnosis codes for ophthalmic diseases can be unreliable and inaccurate, 49,50 particularly in national datasets in which manual validation of data is not possible

While injections remain common and highly effective, next-generation oral GLP-1 medicines, including investigational therapies like ZYOG1, are being developed to make long-term metabolic treatment simpler and more accessible