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In the retina, ganglion cells (GCs) are the sole output neurons that integrate inhibitory signals from amacrine cells and excitatory signals from bipolar cells and transmit the processed information to higher centers [13]

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This inhibitory effect is attributed to the activation of the adenosine monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway and the concurrent downregulation of forkhead Box A1 (FOXA1) and sonic hedgehog (SHH) expression (Xie et al., 2020)

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