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Tirzepatide acts on both GIP and GLP-1 receptors, so it is broader than a GLP-1-only medicine such as semaglutide
Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity
Studies have focused on energy homeostasis, body composition and metabolic pathway modulation via simultaneous incretin and glucagon engagement
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Hypoglycaemia risk is increased when Mounjaro is used alongside insulin or sulphonylureas, and dose reductions of these medications may be needed when starting tirzepatide
