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If you share your feelings or ask a question, they will follow up with questions or provide helpful resources or suggestions

The combination of SGLT-2 inhibitors and GLP-1 RAs offer additive benefits in reducing cardiovascular and renal risk in patients with diabetes and should be considered

The diabetes-induced reduction of neurogenesis in the hippocampal dentate implies a potential mechanism for diabetes-related cognitive decline.105110 A possible explanation is that pro-inflammatory factors in type 2 diabetes compromise endothelial caveolin-1, a major membrane intrinsic protein in the caveolae on the cell surface, leading to vascular dysfunction, affecting neurogenesis, and subsequently leading to AD.111 IKK/NF-B-mediated impairment112 and -aminobutyric acid and glutamate transporter systems113 may also be involved in diabetes-induced damage of neurogenesis

[3] Orthostatic hypotension can occur during hydrochlorothiazide

In both cases, there are important compliance and PBM contractual considerations that need to be explored and fully vetted as part of decision making