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In the general population, adequate dietary selenium intake is safe and beneficial for human health, with a recommended daily intake of 55 g for adults, 0.2 g/kg for children, and 6575 g for pregnant and lactating women [91]

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This discrepancy of iron chelation worsening neurodegeneration characterised by local iron overload raises a critical question: why does iron chelation block ferroptosis induced by pro-ferroptotic agents such as RSL3 and erastin (where there is no iron elevation in cell culture), yet fail to protect in the context of human neurodegenerative disease where iron is elevated

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[DOI] [PMC free article] [PubMed] [Google Scholar] Vanacker V, Guichard M, Bohrer A-S, Issakidis-Bourguet E