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An increased glucose-dependent insulin secretion in pancreatic -cells as well as an increased release of GLP-1 in intestinal L-cells can also be achieved by the activation of GPR119 (Yang et al., 2018), a G-protein coupled receptor (GP(C)R), which is mainly expressed in the small intestine and in the pancreas ( The first dual DPP4/GPR119 modulator was introduced in 2016 by 21

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