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NOX, xanthine oxidase, uncoupled NO synthase, and defects in the ETC lead to excessive ROS generation [407,408], especially the latter one [383,384,409]

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In IBD, the expression levels of tight junction proteins such as ZO-1 and Occludin, is generally suppressed, leading to increased intestinal permeability, enhanced pathogen infiltration, and exacerbated inflammatory responses (Dong et al., 2022)

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