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Article Information Published Online: June 1, 2026

Semaglutide ( n = 4, SUSTAIN-6 [14], PIONEER-6 [15], SELECT [8], SOUL [16])

In a clinical trial, 61 T2DM patients were divided into three groups randomly: liraglutide 1.8 mg/day or liraglutide 1.2 mg/day or glimepiride 8 mg/day

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

Similar content being viewed by others Introduction Glucagon-like peptide-1 (GLP-1) is derived from the cleavage of proglucagon, a protein produced by the intestinal L cells [1]

Moreover, individual metabolic characteristics, such as coexisting diabetes, obesity, or hepatic impairment, influence drug metabolism and response, underscoring the need for personalized treatment strategies