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To determine how GLP-1R activation alters calcium dynamics in VTA dopamine neurons during cocaine seeking, rats were pretreated with vehicle or exendin-4 (2.0 g/kg, i.p.) prior to a cocaine priming-induced reinstatement test session (Fig 6A)

Goes beyond appetite suppression to influence glucose metabolism and energy utilization creating a favorable environment for sustained weight loss

Vella A, Bock G, Giesler PD, et al

Once-weekly dulaglutide versus bedtime insulin glargine, both in combination with prandial insulin lispro, in patients with type 2 diabetes (AWARD-4): a randomised, open-label, phase 3, non-inferiority study

These treatments can result in significant muscle loss, likely due to evolutionary mechanisms protecting against food scarcity as muscle is a major energy utilizer

Exenatide Protects Against Glucose- and Lipid-Induced Endothelial Dysfunction: Evidence for Direct Vasodilation Effect of GLP-1 Receptor Agonists in Humans