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Mechanism of Action Semaglutide works by mimicking the action of a natural hormone called GLP-1 (glucagon-like peptide-1)

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Semaglutide operates through GLP-1 hormone pathways, while antidepressants work on neurotransmitters like serotonin, so direct chemical interference is unlikely

The safety profile of the DPP-4 inhibitors is also favorable and last not least, there are fixed dose combinations with metformin and DPP-4 inhibitors available