glp-1 agonists gastrointestinal side effects constipation diarrhea Managing GI Discomfort on GLP-1s: Causes & Relief Strategies Full article: Managing the gastrointestinal

PMID 41500720

As additional generic versions of Saxenda launch in the coming years, generic prices will likely decrease further.

Because liraglutide shares 97% homology with GLP-1 while exenatide only shares 50% of GLP-1, it is inferred that liraglutide is more likely to mimic the function of endogenous GLP-1

Clinical trials for Wegovy and Zepbound, for example, have shown that users can lose an average of 15% and 20% of their body weight for 68 weeks

The Medicare GLP-1 Bridge program launching in July 2026 will provide access to Wegovy, Zepbound, and Foundayo at just $50 per month for eligible beneficiaries through the end of 2027, with the BALANCE Model providing a long-term path for continued Part D coverage beyond that

Diabetes, obesity, and bone health In conditions such as obesity and T2D, the balance between bone formation and resorption is disturbed, leading to bone health issues