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Abbreviations: BMI: body mass index

In differentiated human adipocytes in vitro , GLP-1 can regulate the expression of adipogenesis and lipolytic genes [47]

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Since cardiovascular complications of diabetes (62, 63) as well as diabetic nephropathy (64) are associated with an imbalance in the activity of RAAS, the interaction with this system could explain some of the beneficial effects of GLP1-RA

While robust synaptic effects have been demonstrated in animal models, consistent replication in humans remains limited, underscoring the need for translational research and validated biomarkers

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