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This likely reflects dose differences rather than efficacy differences, but it definitively disproves the myth that diabetes is required for weight loss response

Glucagon is traditionally known for raising blood sugar, but in this specific tri-agonist configuration, sustained glucagon receptor activation drives thermogenesis (energy expenditure) and promotes lipid oxidation in the liver

Further, administration of exogenous ghrelin in food-sated individuals mimics the enhancement of brain BOLD response to food cues induced by fasting, whereas GLP-1R antagonism prevents the reduction of brain reactivity to food cues after consuming a meal

If you were on semaglutide and only recently discovered pregnancy, inform your healthcare team about the timing and duration of exposure so they can monitor for any potential complications during prenatal screening and ultrasound assessments

A repeat colonoscopy was performed, and gross examination showed diffuse mild inflammation found from 20-40 cm proximal to the anus secondary to colitis (Figure 2)

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