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In the over 2500 participants, who were assigned to the 5, 10, and 15 mg doses of tirzepatide and placebo, the percent weight changes were both statistically and clinically significant compared with placebo

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Malik F, Li Z (2022) Non-peptide agonists and positive allosteric modulators of glucagon-like peptide-1 receptors: Alternative approaches for treatment of Type 2 diabetes

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[DOI] [PubMed] [Google Scholar] 55.Jastreboff AM, Kaplan LM, Frias JP, et al