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Its primary role is to help regulate blood sugar levels by: Stimulating insulin release, which helps lower blood sugar Inhibiting the release of glucagon, a hormone that raises blood sugar Slowing gastric emptying, which makes you feel fuller for a longer period and decreases appetite Because of these effects, GLP-1 receptor agonists like semaglutide have become common treatments not only for type 2 diabetes but also for weight loss management

However, increasingly, data on SGLT2 inhibitors have shown renal and heart failure benefits in people without diabetes, suggesting that people with type 1 diabetes and these comorbidities may also benefit

Weight tracking is particularly important when GLP-1 agonists are prescribed for weight management or when weight loss is a therapeutic goal

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This pharmacological effect is highly relevant for addressing the fundamental pathogenic processes of DR

Meanwhile these agents have the potential to reduce major adverse cardiovascular events (MACE) in patient with T2DM as a drug class, individual drugs have different potency and effects they need tailored approach to align with patient treatment goals rather than generalized use (117)