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Nicotine, a component of tobacco found in cigarettes, cigars, and e-cigarettes, is a highly addictive substance which contributes to compulsive use, relapse after abstinence, and physical dependence

Many of the discovery efforts have been focused on never-smokers as a way of finding these driver mutations, says Geoffrey Oxnard, a thoracic oncologist at Dana-Farber Cancer Institute in Boston, Massachusetts

doi: 10.1160/TH06-05-0257 51

PMID 15091143

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