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India, China, and USA are the worst affected countries bearing the major burden of type 2 diabetes in the world

Natural compounds like curcumin or resveratrol could theoretically slow PD progression by preserving dopamine transporter levels or reducing synuclein accumulation

Biochim Biophys Acta 1960;39:4628

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Isocitrate dehydrogenases (IDH1/2), the enzymes that convert isocitrate to -ketoglutarate in the tricarboxylic acid (TCA) cycle, are frequently mutated in many human cancer types including AML and glioblastoma (Mardis et al., 2009)
