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These compounds showed remarkable binding potential in the substrate binding site of CST protein

Clinical trials have shown that Toujeo produces slightly fewer hypoglycemic events, particularly nocturnal hypoglycemia, compared to Lantus at equivalent doses

These shifts make it more challenging to control blood sugar and may lead to increased hunger and weight gain

M., Wang, Y., & Chen, S

Therefore, while GLP-2R action is required for cold stress-induced jejunal villi lengthening, this adaptation is dispensable for body weight gain in the presence of GLP-1R signaling