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Each interruption triggers appetite rebound and weight regain, requiring re-adjustment and often higher doses to restart

Specifically, if the patients phenotype involves interstitial lung disease, the right ventricle of the heart will encounter chronic increased afterload, which can lead to adverse adaptive responses and remodeling over time

This hypothesis is supported by the finding that GLP-1 induced CICR does not occur in the presence of a VDCC-inhibitor, nifedipine [49]

Additionally, GLP-1 acts on the brain to enhance satiety, making you feel full after meals

Maintenance doses vary based on individual needs and healthcare provider recommendations

Over time, as your body becomes more accustomed to the treatment, this side effect often diminishes