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Dose equivalency between semaglutide and tirzepatide is not straightforward because the compounds differ in receptor selectivity, with tirzepatide acting on both GIP and GLP-1 receptors while semaglutide targets GLP-1 exclusively

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In 2023, the SELECT trial reported that adults with overweight or obesity but not diabetes taking semaglutide for more than three years had a 20% lower risk of heart attack, stroke, or death due to cardiovascular disease, and lost an average 9.4% of their bodyweight

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