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For individuals with severe obesity (BMI over 40 kg/m) or those who have failed other interventions, tirzepatide offers the greatest likelihood of achieving substantial weight reduction

For a typical 18-month course to reach and maintain full response: Compounded tirzepatide: $279-$499/month 18 = $5,022-$8,982 total LillyDirect Zepbound vials (5 mg dose, suitable for many maintenance patients): $499/month 18 = $8,982 Zepbound with savings card and uncovered commercial insurance: $536/month 18 = $9,648 Zepbound at full retail: $1,086/month 18 = $19,548 Zepbound with savings card and covered commercial insurance: $25/month 18 = $450 (annual cap may reset) For long-term maintenance past the initial titration year, similar per-month costs continue

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Semaglutide: Works by mimicking the effects of a hormone in the body that regulates blood sugar levels and appetite

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