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The data from only the mice completing the protocol were analyzed since the most of the Pdx1-Cre;Trp53 R172H ;Rb f/f mice developing insulinoma die within 2 weeks after presenting with hypoglycemia as previously reported 22

The trial also reported secondary improvements in knee-pain scores, which matters for the eventual label scope but does not change the regulatory math for an obesity indication

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While physiological adaptation is a key driver of plateaus, certain dietary and lifestyle habits can also contribute to a stall in weight loss after gastric sleeve surgery