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Although past meta-analyses reported substantial reductions in MACE with DPP-4 inhibitors [23], their conclusions were based on studies with small sample sizes and limited numbers of cardiovascular events, which have not been confirmed by the four CVOTs specifically designed to assess the CV safety of DPP-4 inhibitors

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Holst JJ

2013;24(2) doi: 10.1016/j.tem.2012.11.008

In: Sensory and metabolic control of energy balance , 1st ed

Without medical oversight, patients may experience unnecessary side effects, plateaus, or suboptimal outcomes

A more recent study published in December 2023 found a similar result in tirzepatide, the main ingredient in Mounjaro and Zepbound