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This dual role is particularly evident in contexts of chronic, high-level oxidative stress, such as persistent allergen exposure in severe asthma, and in specific pro-inflammatory immune cells like M1 macrophages, where continuous heme degradation via HO-1 can overwhelm ferritins iron-buffering capacity

doi: 10.1016/j.scienta.2019.04.062 105

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First MB, Williams JBW, Karg RS, Spitzer RL

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In summary, there is evidence that both IGF-1 and MGF could be used to stimulate satellite cell function and proliferation under pathologic conditions