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NTRK gene fusions lead to Trk overexpression or activation, triggering MAPK, PI3K, and PLC pathways [112]
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Differential Diagnosis Conditions that mimic CVS include drug toxicity, increased intracranial pressure, seizures, brain tumor, Chiari malformation, recurrent sinusitis, choledochal cyst, gallstones, recurrent small bowel obstruction, IBD, familial pancreatitis, obstructive uropathy, recurrent urinary infection, diabetes, mitochondrial diseases, disorders of fatty and organic acid metabolism, adrenal insufficiency, and mnchausen syndrome by proxy
