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Rest & Digest Nicotine can influence digestion through two interacting pathways: Indirect fight-or-flight effects through the sympathetic nervous system, which generally inhibits gut function and reduces gut blood flow Direct effects in the gastrointestinal (GI) tract itself via nicotinic acetylcholine receptors in the enteric nervous system and other local tissues Because these pathways can push in different directions, people can experience very different (and sometimes opposite-feeling) GI effects