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Binding of GLP-1 to GLP1R has multiple effects, including enhancing insulin secretion from pancreatic beta cells in response to glucose, increasing insulin expression, preventing beta-cell apoptosis, promoting the formation of new beta cells, reducing glucagon secretion, slowing down stomach emptying, promoting satiety, and improving glucose disposal in peripheral tissues

In vitro studies indicate that GLP-1 and its agonist can act directly on pancreatic cells (46, 47)

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And importantly, nearly one-third of the treated patients stopped the medication , most often because of gastrointestinal side effects like nausea

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