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Three main options: topical creams (daily, easy to adjust, lower commitment), injections (weekly or twice-weekly, predictable levels, requires self-injection), and pellets (subdermal, lasts 34 months, no daily dose to remember)

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231 Given the two distinct outcomes of Notch signal transduction, characterizing the properties of Notch signal transduction, including its broad functional roles, dependence on upstream and downstream signaling factors, precise spatiotemporal specificity, and crosstalk with other pathways, is essential