tobacco leads to cancer Smoking causes The Many Dangers of Tobacco

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Likewise, in human bronchial cells, it has been shown that TS induces increased AP-1 activity, promoting aberrant c-Jun/Fra1 dimerization, which is linked with aberrant phenotypical changes such as hyperplasia, epithelial-mesenchymal transition (EMT), release of EGF ligand, and cell transformation [119,120]

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Manufacturers spray and impregnate reconstituted tobacco paper with nicotine and other substances lost during the process, along with as many as 600 chemical additives