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They suggested that the satisfaction effect was consistent with an efficient transfer of nicotine to the users lungs and a rapid rise in nicotine absorption in the plasma 24

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Grahams letter explains that he had attended a regional symposium on addictions, during which he had learned that the harms of smoking are almost entirely resident in the smoke, while nicotine is relatively harmless.[26] Therefore, he suggested, it should not be beyond the wit of man to separate nicotine addiction from carcinogenesis

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