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In retinal layers such as the inner nuclear and ganglion cell layers, multiple voids and cells with pyknotic nuclei (indicative of apoptosis) were observed

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It depends on the size of the bowl of your pipe

Building on that point, and taking into account the concerns addressed by Trefis, it wouldn't be out of the question for Philip Morris to simply adjust its marketing strategy to better reach older combustible-tobacco users

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It can also be dehydration