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The anti-tumor function of cisplatin, an intercalating agent, has been linked to its ability to crosslink with the purine bases on the DNA, causing DNA damage, interfering with DNA repair mechanisms, and subsequently inducing cell cycle arrest and apoptosis in cancer cells 46

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According to Robert Cunningham, senior policy analyst at the Canadian Cancer Society, smoking rates have declined from 24 percent to 18 percent from 2000 to 2009

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