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With an estimated 20% quit rate during the 2-week run-in period, we therefore plan to recruit approximately 500 participants into the trial until we have 400 eligible for randomization

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So, a circular piece of the sample of the corrugated board is used for the test

Cell Division and Cancer. Scitable , Nature Education, 2014, www.nature.com/scitable/topicpage/cell-division-and-cancer-14046590/#:~:text=Cancer%20is%20unchecked%20cell%20growth,can%20develop%20into%20a%20tumor