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For cardiovascular disease, smoking impairs endothelial function, reduces nitric oxide, and promotes atherosclerosis through oxidized LDL and effects on adhesion molecules (Kunierczyk 2023)

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SPE has adopted a standard protocol to identify, and where appropriate and feasible, eliminate portrayals of tobacco use. Like Paramount, Sony evokes the compelling creative justification rule for including smoking in its youth-rated films, which may include factors such as historical accuracy or an important tie to the creative context of the project and vision of the filmmaker. One pickle for Sony: what to do about films they acquire after production

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