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Alcohol, with 76.4 %, and tobacco, with 39 %, are the two substances most consumed in the last twelve months, according to data from the latest Survey on Alcohol and Other Drugs in Spain EDADES 2022 , published by the Spanish Ministry of Health

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Food Chem Toxicol 118:198203

Integrative analyses showed associations between microbial composition and host gene expression, such as CD74 positively correlated with Lactobacillus and PPP1R3C negatively with Bacteroidota, suggesting that smoking-induced microbial shifted might interact with host transcriptional programs to promote OSCC progression [59]