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Weeks 1 through 4: 1 mg weekly What is happening: Initial GLP-1 receptor engagement begins

Study 2 (NCT04657003): The second study included nearly 1,000 adults who had a BMI of 27 or higher and type 2 diabetes

For the pharmacokinetics studies performed by TechMedILL service (PCBIS platform, CNRS UMS3286), mice were housed in polycarbonate cages (PCT2L12SHT, Allentown) enriched with play tunnels throughout the experimental phase

A further post hoc subgroup analysis was performed for RCTs specifically designed for body weight reduction