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Challenges There are many challenges when implementing such an approach, beyond the already mentioned dearth of clinical risk markers for lung cancer and lung inflammation

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Although both groups had similar frequencies of chronic obstructive pulmonary disease (COPD) exacerbations worsening of the condition throughout the study, menthol smokers had a higher frequency of severe exacerbations at 0.22 per year, compared to 0.18 per year for regular cigarette smokers