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Inhibiting the activity of antioxidant enzymes in the mouse liver resulted in increased ROS formation and oxidative stress (Xu et al

One major limitation is the incomplete knowledge of the metabolic pathways and transformations that polyphenols undergo after ingestion, particularly due to interactions with the gut microbiome and the formation of diverse metabolites whose biological activities are not well characterized (119)

Proc Natl Acad Sci USA 103:1074710752

Metabolic features of cancer cells in NRF2 addiction status

doi: 10.1111/jcmm.13528

Wei RR, Ma QG, Zhong GY, Yang M, Sang ZP (2019) Identification of benzisoquinolinone derivatives with cytotoxicities from the leaves of Portulaca oleracea