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Surgeon General issued an advisory declaring e-cigarette use in youth an epidemic, and since then the FDA, the federal government, and many local governments have proposed several restrictions on e-cigarettes including bans on certain flavors to curb youth appeal (see Supporting Public Health Policies to Reduce the Use of Tobacco Products)

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When nicotine reaches your brain, it triggers the release of many neurotransmitters and hormones that influence your whole body

Carson, J

Looking at their medical records over time helped to identify what the key risk factors were