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Some smokers may have mild to moderate side effects when using NRT but the research has determined that NRT is safe and effective and is generally used in a step-down fashion, meaning that individuals will decrease their dosage of NRT after a certain amount of time until they are completely weaned off nicotine

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Therefore, the present study includes population-based, diabetes-free controls from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study [16], a casecontrol study with a similar set-up to that of ESTRID