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Recreational Nicotine is commonly consumed as a recreational drug for its stimulant effects

Through optogenetics, chemogenetics, and molecular imaging techniques, researchers have systematically elucidated the aversion signaling pathway mediated by 3 / 5 / 4 nicotinic acetylcholine receptors (nAChRs) within this neural circuit (Ren et al., 2011)

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Adrenalectomy attenuates nicotine-induced dopamine release and locomotor activity in rats