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Family and Medical History There is a genetic component to Crohns disease, and large-scale genome studies have identified more than 200 genes associated with IBD and over 71 Crohns disease-susceptibility loci (physical sites within a gene)

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This includes hundreds that are notoriously harmful, and about 70 that are proven to cause cancer

The skin may also look grey, gaunt, leathery or worn, or have a red, purple or orange tone