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It is well known that when some VOCs are combined, secondary pollutants such as formaldehyde (a known nose, throat, and lung irritant) may be produced
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The increased modified proteins and lipids in the circulation of smokers bind to the receptor for AGE, which activates nicotinamide adenine dinucleotide phosphate oxidase and expression of proinflammatory cytokines and chemokines, inducing oxidative stress
