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Around the world, over 8 million people die every year as a result of a smoking-related disease

Some systems related to safety and engine management are required to operate under these conditions

It usually expresses big, dramatic emotion heartbreak, nostalgia, happy tears, or exaggerated despair over something small

These devices, also known as electronic nicotine delivery systems (ENDS), use a battery to generate a weakly heated aerosol based on polyalcohols, such as propylene glycol and glycerol, with a small amount of water containing pharmaceutical-grade nicotine

Peer review Peer review information Nature Medicine thanks Frederic Sitas and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Vapes are still new, so more research is needed to understand the health effects of using them