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As lung surgeon Alton Ochsner wrote in 1939, Inhaled smoke, constantly repeated over a long period of time, undoubtedly is a source of chronic irritation to the bronchial mucosa. Researchers also noted an increase in lung cancer cases, but the incline was commonly attributed to other types of inhaled toxins, like automobile exhaust, tar fumes and factory smog

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All procedures and the experimental design were approved by the Ethical Committee for Animal Research of the Federal University of Ouro Preto (Protocol n 2015/35), according to the Brazilian Society of Neuroscience and Behaviour and the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals (8th edition, 2011)