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Substantial evidence has shown that CS-induced dysbiosis of the respiratory microbiota may drive COPD progression through disrupted microbial-host crosstalk and sustained airway inflammation

However, there is currently insufficient information to determine the exact health effects from long-term use of ENDS/ENNDS products, according to the 2020 report of the WHO Regional Office for Europe

The calculated TSNAs risks surpassed the upper-bound risk advocated by the United States Environmental Protection Agency (EPA/U.S

However, geographical effects appear even more important, accounting for a 29% quality gap (Bai et al

Potential drug interactions can alter the effectiveness of the SNRI or increase the risk of side effects, including anxiety or nausea